e martë, shkurt 22, 2005

Dishevelled and Wnt signaling: is the nucleus the final frontier?

The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.

posted by Selfmaderadio @ 11:57 e paradites