Mechanism of the Excitatory Cl-Response in Mouse Olfactory Receptor Neurons
In vertebrate olfactory receptor neurons (ORNs), the odorant-triggered receptor current is mainly carried by Cl-efflux through a Ca2+-activated anion channel, and it crucially depends on a high intracellular Cl-concentration. Reisert et al. show that a Na+-K+-2Cl-cotransporter (NKCC1) is required for this Cl-current, by maintaining a driving force for Cl-efflux. Surprisingly, immunocytochemistry indicates that NKCC1 is located on the somata and dendrites of ORNs rather than the cilia, where transduction occurs. This topography is remarkably similar to the situation in secretory epithelial cells, where Cl-uptake at the basolateral membrane and Cl-efflux at the apical membrane facilitate transepithelial fluid movement.The context and implications of this work are discussed in a Preview by Restrepo.
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