e martë, shkurt 08, 2005

Shifted from Wnt to Hedgehog Signaling Pathways

Abstract

Two papers in recent issue of Developmental Cell (Glise et al. 2005 and Gorfinkiel et al. 2005) have shown that Shifted, a Drosophila ortholog of Wnt Inhibitory Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism.