At Long Last, CD14 Reveals Its Ligand Binding Secrets
The innate immune response relies on CD14 to recognize several microbial and cellular products including lipopolysaccharide (LPS), a glycolipid found on the outer membrane of Gram-negative bacteria. Once CD14 binds to LPS or another molecule, it presents the ligand to toll-like receptors, which initiate a strong pro-inflammatory response that stimulates host defenses. Jung-In Kim and colleagues have now solved the crystal structure of CD14, providing crucial insights into how the receptor binds to its ligands.
posted by Selfmaderadio @ 10:14 e pasdites
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