Endocytosis of membrane receptors: Two pathways are better than one
Rubén Claudio Aguilar and Beverly Wendland *
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218
Endocytosis pathways are used by eukaryotic cells for internalization of nutrients, signal transduction regulation, and modulation of plasma membrane composition. The cytoplasmic regions of plasma membrane "cargo" proteins harbor signals that are recognized by "cargo adaptor" proteins; this concentrates the cargo proteins at sites of budding for subsequent internalization via an endocytic vesicle. There are several endocytic pathways that can mediate the internalization of many different cargo proteins. The best-studied pathway is clathrin-dependent endocytosis (CDE), defined by a requirement for the protein clathrin, which is the major component of the endocytic vesicle coat. There are multiple clathrin-independent endocytosis (CIE) pathways that generally depend on cholesterol-rich membrane domains (i.e., rafts, which can also be encased by the protein caveolin to form membrane invaginations called caveolae).
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218
Endocytosis pathways are used by eukaryotic cells for internalization of nutrients, signal transduction regulation, and modulation of plasma membrane composition. The cytoplasmic regions of plasma membrane "cargo" proteins harbor signals that are recognized by "cargo adaptor" proteins; this concentrates the cargo proteins at sites of budding for subsequent internalization via an endocytic vesicle. There are several endocytic pathways that can mediate the internalization of many different cargo proteins. The best-studied pathway is clathrin-dependent endocytosis (CDE), defined by a requirement for the protein clathrin, which is the major component of the endocytic vesicle coat. There are multiple clathrin-independent endocytosis (CIE) pathways that generally depend on cholesterol-rich membrane domains (i.e., rafts, which can also be encased by the protein caveolin to form membrane invaginations called caveolae).
posted by Selfmaderadio @ 2:50 e pasdites
<< Home