e martë, shkurt 22, 2005

Getting fat: Two new players in molecular adipogenesis

A transcription factor cascade drives adipogenesis. Two new members of this cascade have been uncovered—Kruppel-like factor 5 (KLF5), which is induced by C/EBPÉ¿ and ɬ and acts in concert with C/EBPÉø, É¿, and ɬ to activate PPARÉ¡2 expression, and Krox20, which is upstream of C/EBPÉ¿ expression and one of the earliest factors induced during adipogenesis.